31 Furthermore, the presence of SSc-associated autoantibodies such as ACA, ATA and ARA is associated with distinct clinical subsets characterised by extent of cutaneous involvement and pattern of organ involvement.
Anti-centromere antibodies (ACAs), anti-topoisomerase antibodies (ATAs), and anti-RNA polymerase III antibodies (ARAs) are three mutually exclusive SSc-associated autoantibodies that correlate with distinct clinical subsets characterized by extent of cutaneous involvement and pattern of organ involvement.
Interestingly, the SSc-associated autoantibodies correlate with distinct clinical subsets characterized by the extent of cutaneous involvement and the pattern of organ involvement [ 15].
These studies suggest that Rbf1, and to a lesser extent Rbf2, interact with distinct classes of genes that show varying sensitivity to loss of Rbf and E2F proteins.
In this minireview, selected monomeric and single b heme proteins endowed with distinct topological properties are inspected for the extent of induced refolding upon heme binding.
Finally, Ste18 [27], [27] displayed a similar extent of polarization as Ste2 with distinct localization in the mating projection, but still substantial staining in the membrane of the cell body.
To what extent these variants correspond to proteins with distinct functions and/or disparate mechanisms of action, or to transcriptional errors, remains to be established.
To the extent that homelessness might be associated with distinct patterns of health service utilization among HIV-infected individuals, relevant policy decisions ultimately must pivot upon clarification of which particular problems need targeting.
The occurrence of different antinuclear antibodies (ANAs) is associated with distinct disease subtypes and with differences in disease severity, including extent of skin involvement, internal organ manifestation and prognosis.
Amongst the reduced genomes, the order and orientation of orthologous gene clusters remain more or less conserved except some local reorientation of genome fragments, the number and extent of reorientations being higher between the strains with distinct light adaptation.
