Sentence examples for with different efficacy from inspiring English sources
This has been evidenced in literature that the compounds of same class behave differently with bacterial strains such as quinolone based antibiotics encounter bacteria action with different efficacy and also face different mode of resistance from bacterial strains as well.
We conclude that long-term captopril administration increased the insulin sensitivity of peripheral tissue in both C and HHTg rats, but with different efficacy.
A variety of synthetic and natural nanoparticles composed of lipids, polymers, and metals have been developed for siRNA delivery, with different efficacy and safety profiles.
Interestingly, Camps et al. demonstrate that AS1 and AS2 inhibit the similar classes of PI3K isoforms, albeit with different efficacy [61].
These results are not necessarily applicable to other SERMs with different efficacy and safety profiles.
In some cases this could mean switching patients to a different antipsychotic with different efficacy or side-effect profile.
Biased agonists, which signal with different efficacies to a receptor's multiple downstream pathways, are useful tools for deconvoluting this signaling complexity.
Anandamide and NADA are two membrane lipid metabolites present in primary sensory ganglion neurons acting on both TRPV1 and CB1 receptors with different efficacies.
In addition, the studies revealed that agonists with different efficacies diverge in their ability to shift the conformational equilibrium towards the fully active state, rather than stabilizing intermediate conformations.
While it has been known for some time that these receptors signal through multiple downstream effectors (such as heterotrimeric G proteins and multifunctional beta arrestin adapter proteins), over the past decade it has been better appreciated that these receptors are capable of signaling with different efficacies to these effectors, a phenomenon referred to as "biased agonism".
This is the first report characterizing local and systemic cytokine and chemokine responses in mice immunized with vaccines with different efficacies against aerosol challenge with virulent F. tularensis subsp. tularensis.
