Similar(8)
trkB is the high-affinity receptor for brain-derived neurotrophic factor (BDNF), a trophic molecule with demonstrated effects on the survival and differentiation of a wide variety of neuronal populations.
Lead is a potent neurotoxicant with demonstrated effects on the brains of children and adults.
Symptoms and findings from the sentinel case and the screened workers are consistent with demonstrated effects associated with n-hexane and other organic solvents.
Since the 1980s, studies have linked BLLs < 10 μg/dL in children 1 5 years of age with decreased IQ and cognition, with demonstrated effects evident at about 2 μg/dL (Jusko et al. 2008).
We note that, in addition to the general considerations expressed above on the choice of candidate genes and populations, the study of SNPs should be more focused on coding variants (that is, with demonstrated effects on phenotype) of genes, although this might exclude other SNPs that are possibly in linkage disequilibrium with genes that are important for disease onset [ 56].
It is possible with the demonstrated effect on central appetite regulation, that there may be effects on animal behaviour, which we did not measure in this experiment, such as a decrease in movement that would account of the similar body weight.
The average apoptosis rate produced by AVO-b was 20% higher than the one induced by AVO-l and, thus, coincided with the demonstrated effect by MTT assay.
The observed upregulation of MMP2 has been reported previously in involuting bovine mammary 61 and agrees with the demonstrated effect of the protein on mammary tissue structure during involution.
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