Previous studies using gene knock-out mice with deficiencies for specific immune functions, including Th1-type cytokines and immunoglobulins, have already shown the importance of both B cells and CD4+ T cells in immunity against B. pertussis [23], [26] [29], [34].
For this purpose we used mouse strains with deficiencies for either TLR-2 (TLR-2-/) or TLR-4 (TLR-4def).
Considering that cadherins and plexins mediate cell adhesion, these studies indicate that some of the abnormalities observed in patients with deficiencies for POMT1, POMT2 and POMGNT1 may arise from defects in cell adhesion and cell cell communication resulting from aberrant O-mannosylation of these adhesive proteins.
PARPi are also investigated as monotherapy for tumors with deficiency of homologous recombination (HR).
Here, mice with deficiency of saposin B were characterized for GSL metabolism and phenotypic development.
Traditional Chinese medicine Bu-Fei decoction (BFD) has been utilized to treat patients with Qi deficiency for decades, with the advantages of invigorating vital energy, clearing heat-toxin and moistening lung, etc.
Estimates are also presented for losses, including childhood cognitive impairment associated with iron deficiency, for Bangladesh, India and Pakistan.
Based on early Chinese medical literature, Danggui can promote blood flow and has been used to treat disorders with blood deficiency (for review see [ 14]).
Routine screening of populations with iron deficiency for lead is also of very limited value because of the low detection rate.
Furthermore, whereas transgenic mice expressing RasV12 display only some features of EMT, compound transgenic mice with a deficiency for p21CIP1 show accelerated mammary tumor formation, which may result from the induction of more extensive EMT features [ 70].
