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There was a trend for cocaine to have its greatest locomotor stimulating effect on wildtype mice, with decreasing effects on heterozygous and knockout mice.
Adding the remaining 11 independent genetic predictors provides accuracy increase and usually with decreasing effects while increasing the number of markers (Fig. 1).
The meta-analysis results reiterate the 'missing heritability' issue (7, 8) but reinforce the impression that increasing the sample size is effective in discovering novel loci but with decreasing effects (9– 11).
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The hearing aids she wore grew stronger, but with decreasing effect.
A stronger protective effect in the youngest children with decreasing effect in older age groups would support Greaves' delayed-infection hypothesis.
Curcumin downregulates the AP-1 binding activity in HeLa cells with decreasing effect on the transcription of HPV-18 [ 38].
The temporal relationship between heat and radiation application seems to impact the effect; simultaneous application leads to greatest thermosensitization effect with decreasing effect as interval between the treatments increases [ 43].
Thus, for these residues, increasing distance from the flavin correlates with decreasing effect on Y. lipolytica complex I. Table 2 reveals that a second set of disruptive mutations, in the FeS domain, are located within 10 Å of the FeS cluster, providing a rational explanation for their effects in both patients and Y. lipolytica.
However, this metaphor needs revision because later reports demonstrated spatial spread of attention that follows a gradient with decreased effects of attention with increased eccentricity from its focus [18] [21].
The most obvious explanation for the higher level of genetic diversity on the younger islands is that large population sizes along with recent population growth have resulted in many new mutations combined with decreased effects of genetic drift.
Therefore, these data support the suggestion that vagotomy may be associated with decreased effects of GLP1 on the endocrine pancreas, perhaps due to the loss of GLP1 signalling via vagal afferents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com