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The catalyst activity increases with decreasing basicity.
Furthermore, the rate of degradation of PPIs decreased with decreasing basicity of the corresponding benzimidazole nitrogen of PPIs, as predicted by the effect of individual substituents on each of the benzimidazole rings.
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We demonstrate that for this series, the affinity is decreased with decreased basicity of the piperidine's nitrogen atom.
The low-temperature activity of the W-containing catalysts could be associated with decreased basicity of the support oxide ions resulting in reduced accumulation of stable carbonate species.
In many of the transformations hERG inhibition follows the expected qualitative trends: decreasing lipophilicity, decreasing basicity, and increasing acidity all decrease the potency of hERG blockers.
Increasing cation radius led to increasing acidity and decreasing basicity, in terms of both total amount of desorbed probe gas and strength of the adsorption sites.
The lanthanide contraction also accounts for the decreased basicity from lanthanum to lutetium and is the basis of various separation techniques.
For aniline, p-π conjunction significantly decreased basicity (determined by electronegativity) of amino groups, which accounted for poor charge-balancing and structure-directing capability.
Clearly, the particle size was well controlled both in the particle size due to the presence of growth substrate of SGP and in the particle dimension due to the decreased basicity.
In these compounds, the decreased basicity of the nitrogen atom could be the cause of this trend.
Where the substituent was an aromatic ring directly attached to the piperidine ring (30), the compound retained reasonably potent activity (EC50=0.024 μ m); however, this compound would have decreased basicity at the piperidine ring.
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