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From November 2004 to October 2006, patients were randomly assigned to receive either initial treatment with imipenem/cilastatin plus vancomycin, with de-escalation starting 3 to 5 days later, based on initial culture results (de-escalation group, DE), or conventional empiric noncarbapenem antimicrobial therapy (non-de-escalation group, NDE).
The government has responded to the FARC ceasefire with "de-escalation" of its own.
To determine factors associated with de-escalation, patients with de-escalation were compared with those with no de-escalation using univariate and multivariate analyses.
The initial SAT is often adapted, with de-escalation to fluconazole when possible.
Second, the number of patients with de-escalation was relatively low.
Patients with de-escalation were compared with those with no de-escalation using univariate and multivariate analysis.
The benefits were mainly ecological with de-escalation in 24 cases and weaning off antibiotics in 11 cases.
To identify factors associated with de-escalation of anti-pseudomonal beta-lactams in the Intensive Care Unit (ICU).
Blood cultures possitives, microbiological documentation and combination of antibiotic therapy were independent factors associated with de-escalation therapy.
Patients with de-escalation had lower ICU mortality rate, compared with those with no de-escalation (42 % vs 60%%, p = 0.017).
The characteristics of antimicrobial treatment associated with de-escalation & its impact on ICU length of stay, hospital length of stay (LOS) and 30 day mortality were determined.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com