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The last one is also a structure alert and is correlated with carcinogenicity [44].
This property is of high public concern because it has a close relationship with carcinogenicity and potentially with reproductive toxicity.
These chemicals were provided with carcinogenicity class assigned on the basis of experiments and extracted from the Leadscope software.
This is the reason why this descriptor was found between the most important descriptors correlated with carcinogenicity.
It is a property of high public concern because it has a close relationship with carcinogenicity and, in the case of germ cell mutations, with reproductive toxicity [1].
The prediction of bacterial mutagenicity is relatively successful (typical accuracies 80%), but the success with carcinogenicity predictions has been much more limited and very few models are available for in vivo mutagenicity.
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"This is a difficult question since when you deal with the carcinogenicity of inorganic arsenic you are dealing with six or more distinct [metabolites]," says H. Vasken Aposhian, a molecular and cell biology professor at the University of Arizona.
Importantly, we treated rats with 0.1 mg/kg bw furan, a dose closer to the estimated highest level of human exposure (3.5 μg/kg bw/day) (European Food Safety Authority 2004), and with 2 mg/kg bw furan, the lowest dose associated with rat carcinogenicity (Maronpot et al. 1991).
Identifying effective alternative remedy with less carcinogenicity is in serious demand.
Environmental awareness and pollution concerns implied ban on benzidine and azo dyes which produce any one of the 22 amines related with their carcinogenicity (Table 3).
Workshop participants agreed that genotoxicity tests in mammalian cells in vitro produce a remarkably high and unacceptable occurrence of irrelevant positive results (e.g. when compared with rodent carcinogenicity).
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