This family is mostly comprised of endoproteases with broad function, many of which enter the secretory pathway [ 56]. S. mansoni also has S26 family members, which contain proteases that are responsible for processing numerous precursor proteins to active, mature forms [ 57].
Amino acid position 757 in TAS1R3 may be involved with broader functions (see below) because of effects on all umami compounds.
In contrast, the 69% of cl-p63BS that do not overlap cl-epidermal enhancers mapped to genes with broader functions including regulation of cell proliferation, tube development, vascular development, and regulation of apoptosis (Supplementary Table S17D).
Lemay et al. [ 19] speculated that pro-lactational stimulus of the mammary gland is not associated with gain of function, but is associated with the suppression of broad functions thereby sparing metabolic support for the specific function of milk synthesis.
The Alba fold is strongly linked with the broad function of nucleic acid binding.
Consistent with its broad function, SPT is expressed in proliferating regions of both vegetative and reproductive tissues, including the root [ 16, 24].
Both PvUbi1 and PvUbi2 displayed high levels of native expression in all tissue types analyzed, consistent with the broad function of ubiquitin in cell-cycle regulation [ 50], DNA-repair [ 51] and other processes required of all cell types [ 31].
Although deletions of SAR1, SEC23, or SEC24 are all lethal in yeast (Lee et al., 2004), consistent with the broad function of ER-Golgi transport, mutations in the genes encoding several mammalian COPII components have been associated with remarkably limited phenotypes, often restricted to a specific cell type or tissue.
Sirt1 is one of sirtuin family proteins which are conserved NAD+-dependent histone deacetylases with broad biological functions [49], [50].
This study highlights that DNA damage, specifically, is the trigger for the modulation of transcripts that encode proteins with broad biological functions.
