First, they tend to identify pathways with broad functions such as proliferation and apoptosis, whose gene members are enriched in the genes with dosage effect.
Amino acid position 757 in TAS1R3 may be involved with broader functions (see below) because of effects on all umami compounds.
In contrast, the 69% of cl-p63BS that do not overlap cl-epidermal enhancers mapped to genes with broader functions including regulation of cell proliferation, tube development, vascular development, and regulation of apoptosis (Supplementary Table S17D).
The Alba fold is strongly linked with the broad function of nucleic acid binding.
Consistent with its broad function, SPT is expressed in proliferating regions of both vegetative and reproductive tissues, including the root [ 16, 24].
Both PvUbi1 and PvUbi2 displayed high levels of native expression in all tissue types analyzed, consistent with the broad function of ubiquitin in cell-cycle regulation [ 50], DNA-repair [ 51] and other processes required of all cell types [ 31].
Although deletions of SAR1, SEC23, or SEC24 are all lethal in yeast (Lee et al., 2004), consistent with the broad function of ER-Golgi transport, mutations in the genes encoding several mammalian COPII components have been associated with remarkably limited phenotypes, often restricted to a specific cell type or tissue.
These data yield novel insight into the broad function of CHDs, with particular relevance to the Class III CHD group and their association with highly severe genetic syndromes in humans.
By its action on the ubiquitination status of PER1, and possibly other clock proteins it interacts with, USP2 appears to exert a broad function, modulating both SCN central clock function (as seen by effects on both period length and response to photic stimuli) as well as peripheral clocks (as exemplified by our observations in embryonic fibroblasts).
"It needs to have an agency with this broader function, to deal with domestic political and development challenges in middle-income countries".
