Antarelix abolished the uterine weight increases with both formula and the diets, whereas body weight was unaffected.
Of the 133 873 measurements, 114 685 (85.7%) were in agreement; that is, they would be classified as normal, mildly decreased, moderately decreased or severely decreased with both formulae.
Among those who developed moderate CKD with either formula, logistic regression was used to model the odds of not having moderate CKD with both formulae (discordance), using forwards selection with P < 0.1 as entry criterion.
In the absence of a large study comparing eGFRs to a gold standard, HIV-infected cohort studies can use either formula, although sensitivity analyses should investigate the robustness of the findings with both formulae, wherever possible.
Of 9521 persons, 9121 (95.8%) had an eGFR ≥ 60 mL/min/1.73 m at baseline with both CG and CKD-EPI, and 9497 (99.7%) had an eGFR ≥ 30 mL/min/1.73 m at baseline with both formulae (Table 3).
Incidence rates and the proportion progressing to moderate and advanced CKD were calculated for both CG and CKD-EPI, in patients with eGFR ≥ 60 or ≥ 30 at the first eGFR measurement with both formulae.
Of 271 who developed CKD with one formula but not the other, 15.1% were HCV-positive, 5.3% were in another HIV exposure group and 14.2% were non-White participants, compared with 23.6, 10.3 and 9.2%, respectively, of the 271 individuals classified as having CKD with both formulae.
There were 49 persons (0.5%) who had advanced CKD with CG or CKD-EPI; of these, 36 had advanced CKD with both formulae (73.5%), nine (18.4%) had advanced CKD with CKD-EPI but not CG, and four (8.2%) had advanced CKD with CG and not CKD-EPI.
A total of 496 persons (5.4%) developed moderate CKD using either CG or CKD-EPI; of these, 271 (54.6%) were classified as having moderate CKD with both formulae (i.e. concordant), 132 with CG but not CKD-EPI (26.6%) and 93 (18.8%) with CKD-EPI but not CG.
While vertical transmission of HIV from mother to child is a risk during breastfeeding [ 18], this risk is increased when the mother feeds the child with both formula milk and breast milk (locally referred to as 'mixed feeding') [ 17, 19, 20].
