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Moreover, the application duration can be too extensive to include the full version of MIA in research with big samples.
As expected with big samples, The Kolmogorov-Smirnov tests showed significance for both the Aboriginal and non-indigenous samples across the three waves (p < 0.001 for non Indigenous and p < 0.05 for Aboriginal at wave 1; p < 0.001 for both non-indigenous and Aboriginal at Wave 2; and p < 0.001 for non-indigenous and p < 0.05 for Aboriginal at Wave 3).
In epidemiological surveys with big samples, use of ICDAS II may become a costly undertaking.
Despite having new studies with big samples and homogeneous criteria for inclusion of AD patients (i.e. NINCDS-ADRDA) compared to the meta-analysis that associated HLA-A2 and AD more than ten years ago [ 12], we did not find conclusive results by this classical approach.
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Though the experiment was set in various conditions with big sample size, the results of correlation analyses seems that theoretically accorded with biological theory in this experiment.
Further investigations with big sample size are necessary for confirming this additive interaction.
In our review, 4 papers [ 8, 9, 23, 29] with big sample size found unrealistic expectations often existed among patients.
Further investigations with big sample size are necessary for confirming this additive interaction and elucidating the exactly underlying mechanism that will shed light on the prevention of CAD.
In addition, further research would be interesting to encompass other driver cohorts (i.e. elderly drivers), since from the current trials did not reveal any clear differentiation between the driver cohorts that were included, despite our original expectations, although we should be skeptical on how this result would differ if the trials would be conducted with bigger samples.
Further research is needed on perceived QOL in OCD patients, with bigger samples and control groups.
Further prospective studies with bigger samples and including traveller groups of different profiles (visitors to friend and relatives, business people, etc).
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Justyna Jupowicz-Kozak
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