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Caffeine abstinence is associated with better efficacy of acute migraine treatment.
Therefore, nonpharmacological therapeutic strategies with better efficacy and tolerance are pressingly needed.
Some outstanding peptides in preclinical and clinical studies with better efficacy and safety profile have already been identified.
It has been also used for preparing thermoreversible gel using Pluronic PF127 and found to increase the drug levels in brain with better efficacy [105].
In this context, computational methods that integrate the knowledge of proteins and drug responses were utilized in prioritizing targets and designing drugs towards clinical trials with better efficacy.
Recently, new medications with better efficacy profiles have been FDA-approved for chronic weight management; however, reimbursement policies that are founded on a legacy of safety and efficacy concerns with previous anti-obesity medications are currently an impediment to access.
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It has been shown to be an effective treatment in P. aeruginosa-driven pulmonary exacerbations in three efficacy studies 29, 79, 80 (also see review by Young et al 81), with a better efficacy when combined with a second antibiotic agent.
These drugs, also called atypical or second generation antipsychotics (SGAs) bring the possibility of a better quality of life for patients affected with schizophrenia, because they have been associated with a better efficacy over negative symptoms, probably less cognitive impairment and lower probability of extrapyramidal symptoms (EPS) [ 2], which is one of their main advantages.
In different treatment guidelines, SGAs have been considered as the first therapeutical option in schizophrenia [ 3- 6], because they have been associated with a lower probability of EPS development, and possibly with a better efficacy over negative symptoms, depression and hostility [ 7].
Therefore, identifying target specific novel antiplatelet and anticoagulant agents with a better efficacy and least side effects is a challenging task for researchers.
For monoclonal antibodies targeting EGFR, it has recently been shown that high expression of EGFR is associated with a better efficacy of the biologic agent (Hambek et al, 2001).
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