"They live with an internalized rejection, and they think that if they are good enough during Ramadan, God will be easier on them for the sins they commit the rest of the year".
Herein we detail the covalent attachment of the NS5A1-31 amphipathic α-helix to MVP, which results in the formation of a new class of nanoparticles consisting of a self-assembling protein shell with an internalized lipophilic core that is capable of reversibly sequestering small lipophilic compounds of interest for vault-mediated drug delivery.
If, as with the inner mitochondrial membrane, the mechanism differs from that used for the plasma membrane, this would be consistent with the nucleus being an internalized cell.
Induced desmosome assembly mediated by EGFR inhibition is thought to stabilize desmosomal components at the intercellular junctions by interfering with their accumulation in an internalized cytoplasmic pool.
Indeed, GRAF1-positive tubules, and other GRAF1-positive structures, were devoid of Clathrin and did not colocalize with internalized or internalizing transferrin or the transferrin receptor, which is widely used as a marker for Clathrin-mediated endocytic events.
Cells expressing high levels of the Tac transgene have, in addition, a second internal accumulation of Tac, which colocalizes well with a pulse of internalized transferrin.
Figure 5D shows a macrophage with internalized melanosomes, evidence of the phagocytosis of tumor cell products.
Antibody-induced pSn endocytosis was only partial, since confocal microscopical analysis showed that, together with visible internalized Sn, a clear plasma membrane staining could still be observed, even at 90 min when endocytosis was visible in most cells (Fig. 1b).
It comes with a tinge of internalized homophobia and self-flagellation, and, quite frankly, it's boring and misses the point.
I had never really been around other people who looked like me and I think, looking back as an adult, that wasn't good, because I grew up with a lot of internalized racism that I am still unlearning to this day.
I had never really been around other people who looked like me, and I think, looking back as an adult, that wasn't good, because I grew up with a lot of internalized racism that I am still unlearning to this day.
