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A 1.5-fold increase in serum lactate after OLT correlated well with all complications observed.
In contrast, after further adjustment for TNF-α (Table 2, model 3), NT-proBNP was no longer significantly associated with all complications and CVD.
Overall, moderately strong associations were seen with all complications, before adjustment for mean HbA1c over time, which rendered these associations nonsignificant with the exception of sustained AER >30 mg/24 h and CAC, which were largely unaffected by adjustment.
The model with all complications, retinopathy, albuminuria (AER), and peripheral neuropathy, showed that peripheral neuropathy (2.75 [1.60–4.75]) and albuminuria (1.71 [1.39–2.10]), but not retinopathy (1.29 [0.69–2.39]), were significantly independently related to all-cause mortality.
If we further included office CASP or office CPP in the adjustments, both 24 h-CASP and 24 h-CPP remained significantly (p ≤ 0.045) associated with all complications except albuminuria (data not shown), suggesting additional risk information of 24 hour measurements as compared to office measurement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com