We address this issue by modeling the optimization of the composite network and the prediction problems within a unified objective function.
Yu et al. [ 25] proposed a method, called ProMK, that combines the composite network optimization with respect to a group of functions and the network based classifier in a unified objective function.
Unlike the aforementioned methods, MNet jointly optimizes the multiple network integration and the network-based classifier for a set of function labels in a unified objective function.
MNet iteratively optimizes the weights assigned to the individual networks and the loss of the classifier according to a unified objective function.
A unified objective function with variable design priorities represented by function weights of the two topologies is proposed and examples are illustrated.
"The unifying objective," they say, "is to avoid becoming a unified object".
In addition, MNet takes into account the unbalanced label problem in protein function prediction, and incorporates a label weighted scheme into the unified objective function to give more emphasis to the functional labels with fewer proteins.
"And that's part of the reason why, when I see a situation like this one, where we can achieve an objective with a unified world behind us — and we preserve our hedge against it not working out — I think it would be foolish, even tragic, for us to pass up on that opportunity".
It rather implies that empirically observable motions must be subject to a priori principles of the understanding (a priori rules of time determination) in order to count as fully objective experience within a unified, temporally determinate objective world.
Senior officials, including the chairman of the Supreme People's Assembly, Choe Thae Bok, insisted to me that over the next two years the new priorities will be "prosperity and dignity," with a "unified, denuclearized Korea" as their first objective.
The parties released a joint written statement, capping an often-contentious negotiation with a unified voice.
