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Figure 2 shows results with a true error of 10−4 miscalls per base.
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These performance metrics include the first, second, and cross moments of the Bayesian MMSE error estimator with the true error of LDA, and therefore, the root-mean-square (RMS) error of the estimator.
It also provides background about the origin and goals of the PTE project, outlines the special challenge associated with estimating the true error of models that aspire to predict open-system behavior, and summarizes what has been learned to date.
Reassessment of errors by the study team resulted in exclusion of a total of 143 errors which were not considered true errors of the process of prescribing.
The mean error rate is then calculated as an estimation of the true error rate of the classifier.
For example, measurement error of only about 10% in analysis of a sample with a true copy number of 6 would result in an incorrect integer call.
The number of error trials with low confidence (true error) was miniscule and almost identical between the two groups.
This design has a less than 5% probability of rejecting a treatment with a true response rate of 20%, and provides an estimate of the response rate with a standard error of approximately 10%.
Having the complete response rate as primary end point, Simon's optimal two-stage design for phase II trials was used to calculate the sample size: with an α error of 0.05 and a β error of 0.10, P0 (clinically uninteresting true complete response rate) and P1 (sufficiently promising true complete response rate) were set at 10 and 30%, respectively.
Therefore, the error bars estimated with our approach will in general be an underestimation of the true error bars.
Two thousand replications for each set of parameter combinations were sufficient to estimate the power with a margin of error of 1.75%, assuming that the true power was 80%.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com