Sentence examples for with a substantial problem from inspiring English sources

But, he warned, "It does leave us with a substantial problem in the next year -- as we have to make these major infrastructure investments -- about where we're going to get the capital".

However, poor compliance with therapy is a substantial problem that affects 20%to70%0% of the patients during follow-up [ 5- 16].

Suicide represents a substantial problem, with significant societal and personal impact.

A substantial problem with asset protection planning has long been that evidence of such planning puts a debtor in a bad spot with judges, who by and large do not look upon such planning favorably.

Thus, our results confirm that the Signature MPSS method fixes a substantial problem with the Classic MPSS method.

The weights and the direction of the bias for the individual items is a substantial problem with scales.

As these materials can vary widely in their texture, they can pose a substantial problem with respect to cleaning and disinfection, and therefore act as potential sources of MRSA and C. difficile transmission and dissemination.

A substantial problem associated with all these new toxins is the extreme difficulty associated with the study of their toxic effects and mechanisms of action due to the very small quantities of purified toxin available.

Yet studies using other measures have shown that depression is a substantial problem among individuals with arthritis particularly RA [ 32].

Neurological complications of paediatric cancer are a substantial problem and are associated with significant morbidity and loss of quality of life for long-term survivors of paediatric cancer.

A very substantial problem with this group of sampling is that it is limited to the studies around the content of shared topics, which is not scalable to many applications.