In the synovial membrane of patients with RA, there is a substantial expression of IL-15, predominantly expressed in macrophages but also in fibroblast-like synoviocytes and endothelial cells [ 3- 5].
WISH of wild-type worms revealed a stem cell-like expression pattern with substantial expression peripheral to the stem cell compartment.
Adenovirally delivered GFP and LacZ were strongly expressed in injured rat carotid arteries, with substantial expression found in the media, adventitia, and neointima, as indicated by PCR GFPP only) (see Supplementary material online, Figure S5A ) and immunohistochemical staining (see Supplementary material online, Figure S5B ).
Three lines with substantial expression of Lck protein, namely NCI-H548, SKCO-1 and SW620 cells, were detected.
and therefore are expected to display substantial expression differences compared with ALL cells that are unrelated to somatic variants.
In summary, inter-individual variability along with a substantial dissociation of mRNA expression pattern and protein levels seems to be a characteristic of CYP expression in the colon as has been reported in part by others before [ 12, 14, 17, 18].
Along with a substantial increase in Tbx3 expression, both c-Myc and Dpp4a were significantly reduced in Oct4 t-hPSCs.
The growth defect was associated with a substantial decrease in the expression of targeted genes (Fig. 5).
Probes with a substantial likelihood of differential expression under treatment conditions were identified using simple t-tests combined with mean fold change in accordance with recommendations from the Microarray Quality Control (MAQC) Consortium (Guo et al. 2006; Shi et al. 2006).
A similar effect was observed with albumin D-element binding protein (DBP), a direct clock controlled output gene that is thought to be the dominant circadian regulator of Cyp7A1 expression [9], [43], [44], [45], with a substantial blunting of the peak expression at ZT10 in the PERDKO mice (Figure 6A).
We have analyzed also the direct co-culture of tumor cells with MSC, only pretreated with cisplatin, which changed the substantial expression of many genes compared to tumor cells cultivated with untreated MSC (Fig. 5a).
