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A combination of one epigenetic event with a splicing gene alteration is frequent.
These results are consistent with the aforementioned report that PUF60 interacts with a splicing enhancer that is important for exon 8 splicing [19].
The short version of AtIPS1 was found to interact with ATXR6 and with a splicing variant of ATXR5 lacking its PCNA binding site [7].
PQBP1 includes two protein interaction domains: WW domain (WWD) through which PQBP1 interacts with RNA polymerase II and NpwBP [2], [3] and C-terminal domain (CTD) through which it interacts with a splicing factor, U5-15kD [4], [5].
These findings also show that the metastatic process appears to be associated with a splicing switch.
Metastatic melanoma is associated with a splicing switch to pro-angiogenic VEGF-A, previously shown to be regulated by SRSF1 phosphorylation by SRPK1.
Similar(46)
Sometimes it's a thrilling big-beast collaboration, with a splice of sexy names.
As Mr. Wolfe wrote, "Plunging in on those miles of bouncing, ricocheting, blazing film with a splicer was like entering a jungle where the greeny vines grew faster than you could chop them down in front of you".
"With a splice database, I imagine finding sound effects will be as easy and accurate as the sample library, and that would be super helpful working on sound design projects".
GFP trapping was successful using vectors designed for integration into regions encoding exons and vectors that were engineered with a splice acceptor site for integration into regions encoding introns.
The model predicts that ARHGEF7 coordinates receptor signaling with cytoskeletal proteins and also makes interactions with a splice factor SFRS9 which can regulate alternate splicing events.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com