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This indicates that there may be residual nbr activity for those functions that is worse with the catalytically dead form or that nbr functions in a complex with a more severe effect when a catalytically compromised protein is expressed.
Both hFXNG130V and hFXNI154F clones showed a significant decrease in the mitochondrial succinate dehydrogenase (SDH) activity with a more severe effect in the hFXNI154F mutants compared to the hFXNG130V mutants with 36% and 54% residual SDH activity, respectively (Fig. 5A).
Low-flow Priapism (LFP) is a rare condition, but with potential severe effect on the erectile function.
The LRBA treatment had a more severe effect with the IV decreasing by 27%, and 32% of individuals being removed (Table 5).
An example of waveform of dynamic pixels (Fig. 3A) of a terfenadine-treated embryo with severe effect and its corresponding power spectrum (Fig. 3B) were shown.
mig-13 and sdn-1 both affected anterior AQR migration, with mig-13 having a more severe effect (Table 4).
The D442G acts in dominant negative manner with severe effect in heterozygous state [ 14].
5 FD is a multiorgan disease with severe effects on cardiac, renal, cerebrovascular, ocular and neural function.
This larger amount of MeHg affects a larger amount of water, with potentially severe effects on the ecosystem in Hunnbunn.
Rheumatoid arthritis (RA) is a chronic, inflammatory disease with severe effects on the functional ability of patients.
It strongly suggests that E-cadherin transcriptional inactivation is an epi-phenomenon and part of an entire programme, with much more severe effects than loss of E-cadherin expression alone.
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