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This peptide has a specific function -- it binds with a receptor on human liver cells.
There it combines with a receptor molecule in the postsynaptic membrane (or end-plate membrane) of a muscle fibre.
(For H.I.V. to infect immune cells, for example, it must normally dock with a receptor that sits on the surface of those cells. There are people, though, whose genes instruct them to build defective receptors. Those with two copies of that defect, one from each parent, are resistant to H.I.V. infection no matter how often they are exposed to the virus).
With the exception of the steroid hormones, most hormones such as insulin and glucagon interact with a receptor on the cell surface.
With the availability of powerful computers and sophisticated graphics software, it is possible for the medicinal chemist to design new molecules and evaluate their potential interaction with a receptor or an enzyme before they are synthesized.
The ability to respond to virtually any antigen comes from the enormous variety of lymphocyte populations that the body contains, each of them with a receptor capable of recognizing a unique antigen.
Similar(5)
While ESAT-6 will disrupt lipid bilayers (indicating a cytolytic function [9], [12]), structural analysis of the ESAT-6/CFP-10 complex suggests another role more consistent with a receptor-mediated interaction with host cells [13].
MWS is a genetic condition caused by heterozygous mutations or deletions of ZEB2 (zinc finger E-box binding homeobox 2 gene), a protein that interacts with a receptor-mediated, activated full-length SMAD.
This transfer is accomplished by redirecting T cells with a receptor-recognizing defined antigens on a cancer cell [ 5].
All serum samples were treated with a receptor-destroying enzyme and absorbed with fresh turkey erythrocytes to remove nonspecific inhibitors before the assays.
Finally, we determined whether dominant-negative inhibition by a non-DNA binding PPARγ mutant could interfere with a receptor-mediated biological process.
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