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The permutated P value or FDR for pathway enrichment was calculated with a permutation number of 300.
The latest go-round of "The Bachelor" began just last week with a permutation meant to trump the faux moneybags appeal of "Joe Millionaire" with a real heir to a real fortune: 27-year-old Andrew Firestone, great-grandson of the tire magnate Harvey Firestone.
A particular case of the famous quasispecies model — the Crow Kimura model with a permutation invariant fitness landscape — is investigated.
Defining G ≜ BA the combined mixing-separating matrix, the BSS problem is solved if G is a so-called trivial matrix, i.e., the product of a diagonal matrix with a permutation: these are well known ambiguities of BSS.
Additional file 1 provides detailed information about the performance curves and the necessary specifics for benchmarking novelty scores with ROC curves as well as significance testing of AUC ROC with a permutation test (see also Additional file 2).
While it is possible to envision several ways to address this issue (depending on the activity landscape method), in this work we specifically employ the SALI formulation of activity cliffs and combine the idea of threshold-based identification of SALI cliffs [4, 8] with a permutation test to identify significant activity cliffs–significant in the sense of magnitude as well as statistics.
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For screening purposes, we selected those SNPs with a permutation-based p-value below 0.05 in the conditional test.
Seventy-one small genomic regions were significantly differentiated between serpentine and granitic samples (windows with a permutation-based FDR<0.001 were considered significant, see methods).
Clusters of gene modules that appeared the most relevant to differentiate [PIP+] and [PIP−] subgroups were identified using t-statistics with a permutation-based adjustment of the gene expression matrix (n = 10,000 and α = 0.05).
Results were considered significant with a permutation-based P-value < 0.05 after 1000 permutations.
Using a method called geometric fold change (GFC), they identified 133 differentially expressed genes (139 probesets) with a permutation-based false discovery rate of 2.3 × 10-3; Of these, 12 genes (13 probesets) were confirmed by RT-PCR.
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