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No specific threshold was set and the filter was passed even with a minimal difference between the groups.
Baseline characteristics (Tables 3, 4) were balanced with a minimal difference in terms of previous PC training in the intervention group (78%) vs. the control group (70%).
The sample size was calculated based on an alpha error of 0.05 and a beta error of 0.2, with a minimal difference of 20% in terms of the intubation success rate (compared to 65%).
To illustrate the clinical significance of the variation in QoL, the within-group changes in EORTC QLQ-C30 scores (follow-up scores minus baseline) were categorized in three classes, improvement, no change, or deterioration, with a minimal difference, of either 5 points or 10 points, defining a little change or a moderate change respectively [ 26].
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Two investigator-blinded trials of 238 255 g PEG in 64 oz of Gatorade and 10 20 mg bisacodyl compared with a 4-liter PEG-ELS found better quality preparations with the PEG-ELS and only a minimal difference in tolerability.
With a minimal relevant difference of 6 ml/min with an estimated standard deviation (SD) of 4 ml/min 18 subjects were needed using a level of significance of 5% and a statistical power of 80%.
These results suggest that children with the disorder do not, according to their perception, experience prejudice or difficulty in physical functioning, showing good agreement with their parents, with a minimal average difference between the scores.
The power analysis in the FINALE - Clean study was based on work ability with a minimal relevant difference of 10% in a paired design and a power of 0.8 and a statistical significance level of 0.05.
We calculated that a study size of N=8000 would provide 88% power to examine all between-factor analyses with a minimal detectable difference in basic R of 0.1.
With a minimal relevant difference of 0.6 mm total translation (power 90%, alpha 0.05, SD 0.6) the study was powered for 22 patients in each group (Ryd et al. 1995).
The power calculation for this study was based on improvement in asthma-specific quality of life, with a minimal important difference of 0.5 points on the 7-point overall scale in the Asthma Quality of Life Questionnaire (AQLQ) or the Paediatric Asthma Quality of Life Questionnaire (PAQLQ) [ 9- 11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com