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TMP (10−10 10−5 M) exhibited an increase in PS with a maximal increase of 30.9%.
In our experiments 1,2-epoxypentane was mutagenic at and above 100 μg per plate with a maximal increase of about 6-fold at 5000 μg per plate.
Increased MNHEP were observed in the liver related with the dose with a maximal increase of 11-fold which was close to significance (Pearson coefficient = 0.44; P = 0.054, Tables 3 and 4).
Micronuclei in PCE showed increased frequencies with the higher doses with a maximal increase of 2.7-fold and a Pearson correlation with the treatments with a coefficient value of 0.57 and P = 0.007 (Tables 3 and 4), whereas %PCE showed no significant change.
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For across-lineage heterogeneity, we simulated nucleotide sequences with 30% G+C content; in non-sister lineages B and D, G+C content was increased by a variable amount, from no G+C increase up to a maximal increase of 70% (producing sequences with 100% G+C).
SMT022357 shows a maximal increase of 3-fold in luciferase compared with vehicle (Fig. 1A).
Expression of the CXCL8_L2 gene was quickly and significantly upregulated in peritoneal leukocytes at 6 48 h after zymosan injection, with a maximal increase at 6 h of inflammation (Fig. 6a).
LDN-76070 was most active at a dose of 370 nM with a maximal increase in SMN protein level of 1.8 ± 0.3-fold averaged over three experiments.
A time-course study revealed that exposure of MEF cells to MSU crystals (2 mg/ml) enhanced IL-1β secretion, with a maximal increase at 36 h, while that of TGF-β1 had already occurred by 12 h.
Following the 12 g dose, mean chloride concentrations increased from 101 (95%CI: 99 to 102) to 103 (95%CI: 102 to 104) mmol/L (normal range 97 110 mmol/L) (Figure 5B), with a mean maximal increase of 3 mmol/L (range 1 to 5; p<0.001).
A dose-dependent rise in ATP concentrations by pyruvate was observed both after 30 and 120 min (Fig. 2A and B), with an average maximal increase of 56 ± 14 and 27 ± 3%, respectively (Table I).
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