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23 Hospitals with a lower depth of coding were disadvantaged because this was associated with a lower Charlson index, which in turn underestimated the expected mortality and so inflated the standardised mortality ratio.
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A region with lower depth that measured 6.8 to 7.1 Mb on chromosome 8 was consistent with a cluster of retrotransposons (data not shown).
A maximum number of CNV was detected for Cervil (with 641 regions showing a significant lower depth and 234 regions a higher depth (Additional file 7).
Eléazar and the Jews are ghettoized into a subterranean lower depth, with basic black chairs and tables and weary-looking families in gray dresses and three-piece woolen suits.
Thus, we suggest that it would be more prudent to sequence many individuals with lower depth rather than a limited number of individuals with high depth.
For further decreasing in the ionic strength (IS < 20 mM), the cells are gradually detached due to the increase in the energy barrier (Fig. 6a), and the secondary energy minimum migrates farther from the surface with the lower depth (Fig. 6b).
Iterative scaffolding (4 iterations) using a low sliding window for 3 out of the 4 iterations (− t 5) completed in 1h52m and required 84 GB using the 118-fold raw PacBio data set and 3h05m and 151 GB RAM with the lower depth (28-fold) ECTools-corrected Tools-corrected PacBio
In the present study, we systematically evaluated SNP detection performance of three strategies to utilize the duplicated exome data of 92 subjects, only using the data with higher depth, only using the data with lower depth, and using the merged data from technical replicates.
With a ten-fold lower input (4,800 C. trachomatis genomes) we obtained 98% coverage of the reference genome but with a lower mean read depth.
Contigs supported by an average read coverage depth of less than five-fold are also excluded since contigs with lower depth might be less reliable.
Positive agreement between self-report and hospital records was significantly lower for hospitals with lower depth of coding across all morbidities.
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