Representative examples of these responses are shown in Figure 2A and B. In line with the ELISpot data, we found a higher breadth of responses in LTNPs by ICS analysis with LTTS and LTNPs subjects targeting a median of 2 (range 1 5) and 5 (range 1 9) epitopes, respectively (P = 0.001).
When the information on the differential molecular function of paralogs was insufficient, we chose the copy with a higher expression breadth.
Expression breadth, however, shows a contrasting pattern, i.e. longer genes have higher breadth of expression, possibly to ensure those structural features associated with gene plasticity.
The strengths of the study include a nationally representative sample with a high participation rate, the breadth of indicators of childhood circumstances and the potential to study their concordance with current circumstances and several indicators of health behaviour.
The entries of column E of Table 1 show that the RSCU' of most codons is either positively or negatively correlated with breadth of expression, indicating that indeed the high codon bias in the genes with low breadth of expression results from preference for different codons than in the genes with high breadth of expression.
A population of generalists is thus characterized by a high niche breadth, while resource specialization results in low niche breadth.
The combination of two mAbs expanded the breadth of protection with a high level of efficacy and safety associated with potential immune escape variants.
These patterns form "cascades" with different profiles: for instance, a fast-spreading rumor that's quickly snuffed out would have high breadth but little depth, and low virality.
Namely, there is a strong depletion not only of "high rate/low breadth", but "high rate/medium to medium-high breadth" categories of sites and proteins.
Quality of written English: Acceptable Response to Reviewer 2 (Arcady R. Mushegyan) There is a strong depletion not only of "high rate/low breadth", but "high rate/medium to medium-high breadth" categories of sites and proteins.
