Despite the considerable interest in TRAIL or agonistic TRAIL-receptor antibodies as anticancer agents, accumulating evidence suggests that indeed mono-therapies with these agents may have limited success, but that synergistic treatments with other apoptosis inducers may be a good rationale to efficiently activate apoptosis in many types of cancers [53], [56] [59].
However, our previous studies, demonstrating an increased abundance of LPS-rich Proteobacteria, particularly Escherichia coli, in association with adenomatous states [ 13, 14] provide a good rationale for evaluating bacterial endotoxins, inflammation and adenomas.
The adverse impact of stress, coupled with urbanization and weak health infrastructure provide a good rationale why systems-thinking approaches could be essential for the effective management and optimal hypertension in West Africa.
Therefore, at the physiological temperature, the core CEs being in a liquid-like state, the lipid-lipid interactions with an intrinsically self-organizing energy optimum provide a good rationale for the overall spherical shape of the LDL particles.
Kt/ V has not yet been validated as a marker of adequacy in patients with acute renal failure, but it seems that a good rationale exists for its use in continuous therapies.
Clinically, there appears a good rationale for this theoretical distinction, with increasing recognition of referred sources for muscle pain in many of our athletes.
There is a good rationale for such a combination, with one targeting postprandial and the other fasting plasma glucose, providing additive effects on HbA1c, and one associated with weight loss and the other with a degree of weight gain.
The signaling nature of the effect of dietary restriction provides a good rationale for the results of experiments with methionine.
As an immunologist who has a family member with Asperger's syndrome, I do not believe that this is a good rationale for exemption from vaccinations.
