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Together, the data are consistent with a direct association of the 163+37235A-allele with an increased susceptibility to DGC.
There were, however, effects on hormone dependence and tamoxifen sensitivity with a direct association between HER 2 overexpression and estrogen independence as well as tamoxifen resistance.
Moreover, one study suggested differences in effects of animal and plant protein, with a direct association of animal protein and risk of overweight and obesity, and an inverse association for plant protein [ 14].
In the general population, one study suggested differences in effects of animal and plant protein on weight, with a direct association of animal protein and risk of overweight and obesity, and an inverse association for plant protein [ 14].
160 Despite the growing number of positive studies, the Syst-Eur study remains the only recent study with a direct association between antihypertensive use and a decrease in the incidence of dementia.
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A study by Coultas et al. [ 24], however, have found impaired personal capabilities even in COPD subjects unaware of having the disease, which is consistent with an direct association between mild COPD and health status.
Similar to ERM proteins, the open conformation facilitates localization of merlin to the membrane where it associates with receptors, and indirectly, with actin through a direct association with beta II-spectrin (Scoles et al., 1998; Grönholm et al., 1999).
This may have introduced bias given that BMI is a negative confounder between breast density and breast cancer risk (that is, it has an inverse association with the former and a direct association with the latter) and is associated with poorer breast cancer survival [ 25].
Low condom usage in receptive anal intercourse with casual partners had a direct association with HIV seropositivity, whereas insertive anal intercourse with casual partners with or without condoms were inversely related.
StcO2 and BIS have an inverse association with ICP and CAP Index, and a direct association with CPP (Table 3).
This suggests that particular SNPs may be associated with the clinical covariates rather than having a direct association with DR. We found the DR-associated SNP rs9640883 to also be associated with duration of diabetes.
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