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Either platelet derived growth factor (PDGF) or retinoic acid (RA) prevented neurosphere formation from dispersed secondary neurospheres and resulted in cells with a differentiated morphology (Supplementary Figure 1C) and expressing markers of differentiation.
PPAR activation in non-small cell lung cancer cell lines resulted in growth arrest, irreversible loss of capacity for anchorage-independent growth, decreased activity and expression of matrix metalloproteinase 2 and modulation of multiple markers consistent with differentiation as well as the upregulation of markers consistent with a differentiated state [ 29].
This development was possible only because Athens had become a large city with a differentiated culture that gave the individual ample choice of a way of life, including religion.
Instead, look for companies with a differentiated borrower channel strategy addressing needs beyond refinancing.
End-to-End (E2E) differentiated services refer to information services, delivered over the modern Internet with a differentiated grade of Quality of Service (QoS) over heterogeneous networks.
"We plan to relaunch eBay India with a differentiated offer to focus initially on the cross-border trade opportunity, which we believe is significant," the company noted in its statement.
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The unmodified appearance of the surface is consistent with the absence of a differentiated interior.
After prolonged treatment with these pharmacological agents, a differentiated phenotype was observed in both cellular models.
Finally, we tested whether Hdac6 interacts with Tip60-p400 complex in a differentiated cell type, MEFs.
While the predominant part of the tumor was moderately differentiated, foci of single atypical cells infiltrating the pancreatic parenchyma, consistent with a poorly differentiated component were also noted.
MYCN amplification is associated with a less differentiated ultrastructural phenotype, and lack of MYCN amplification with relative ultrastructural neuronal differentiation.
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