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New conformations starting from the X-ray native structure are generated by random perturbations along with a constraint to increase the radius of gyration.
The geographic information systems (GIS) -based accessibility analytical framework described in this study applies vehicle routing and heuristic computations to location-allocation of warehouses to potential sites by optimising transport cost with a constraint to provide service to at least 90% of delivery demand.
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The full library of 11025 peptides was docked to the Aq comparative model [14] using FRED [34], with tuned settings and a constraint to restrict the positioning of Lys264 (see File S1).
In order to deal with this problem, we provide a constraint to limit the matching range of images for the current position to determine the loop closure image.
The parameter identification procedure used a maximum likelihood random-walk strategy with a correlation constraint to identify a diverse family of likely parameter sets (Fig. 2C).
For this purpose, we combine the generic BSS with a geometric constraint to force a spatial null towards the direction of the target source.
The concept combines BSS with a geometric constraint to cope with the underdetermined scenario such that a meaningful and joint estimate of all interfering speech signals and diffuse background noise can be obtained using only two microphones.
A mixed algorithm developed by O'Hanlon et al. [76] uses a greedy approach to select the notes that are the most efficient to model a mixture, but applies NNLSQ, with a sparsity constraint, to improve the estimation of their ratios.
Each spatial temporal bin is inverted for stress orientation, with a flattening constraint to minimize the difference in stress orientation between adjacent spatial bins and between consecutive time periods.
Most recently, Ullah and Finch [ 23] used constrained penalized regression splines with a monotonic constraint to represent their smooth curves of falls incidence rates.
If in both species the most conserved X-X orthologs are the only two genes with a selective constraint to maintain the ancestral function, the less conserved X-X orthologs may diverge randomly.
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