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A multi-centre, randomized, double blind, controlled trial to evaluate the effect of a probiotic vs non-probiotic dairy product on symptoms in IBS with a constipation element (IBS – Constipation or IBS – Mixed profile).
This carefully conducted double blind randomized 12 week study assessing a wider range of outcomes in a general population of IBS with a constipation element, did not reproduce these earlier hospital based findings.
However the heterogeneous nature of the cohort recruited (some with a constipation predominant form of IBS and others with a mixed profile) may further mask an effect which would be demonstrated in a more homogeneous IBS constipation predominant patient group.
In this double-blind randomized controlled trial of a commercially available probiotic fermented dairy product (yoghurt) containing bifidobacterium animalis DN-173010 in community based IBS patients with a constipation element, both the inactive (control) and active product groups demonstrated significant improvement across a range of symptom and quality of life outcomes.
Similar(56)
Reduced frequency of bowel movements is a common finding, with severe constipation being a significant problem in several cases [13,16,18].
In a small pilot study in The Netherlands, 8 consecutive children with untreated constipation with a defecation frequency < 3 per week and hard stools were treated with the fermented milk 2 times/day for one month.
The observation that abnormal serotonin signalling and reuptake appears to play a central role in the symptoms of a subset of patients with chronic constipation provides a rationale for the use of targeted serotonergic agents for the treatment of chronic constipation (Cash & Chey 2005; De Maeyer et al. 2008).
Rectal prolapse, in which the membrane that lines the rectum protrudes through the anus, occurs frequently in elderly people with a history of constipation and straining during bowel movements.
Those adults with a history of constipation going back to childhood may have adapted to the condition.
Therefore, the aim of this study was to compare current HRQoL in young adults with a history of constipation with peers from the general Dutch population.
And if you're a parent of a kid with regular constipation, get it checked out!
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com