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The model compared bevacizumab (1.25 mg in 0.05 mL per injection) with a comparator of mixed standard care in the UK in 2009 (16 patients received PDT, 38 patients received pegaptanib, 12 patients received sham injection) based on clinical assessment in the ABC trial.
A number of these studies illustrated superior performance of RNA-seq over microarrays in dynamic range and number of differential genes with a comparator of Affymetrix microarrays [ 5, 7– 9].
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We believe that our study, comparing outcomes in over 176 000 women undergoing induction of labour with a comparator group of 900 000 women provides strong supporting evidence that elective induction of labour is not associated with a consistent increase in caesarean section rates.
It ended the year with assets under management worth £6.4bn, up in a year from £5.4bn which represents an increase of 19%, compared with a comparator market figure of 13%.
Dinh, Rosner et al. considered the approach of general population screening using a risk prediction tool (PREMM126) [ 29] in primary care with a comparator arm of "current practice" and found that screening individuals at various ages with a predicted risk of carrying LS of 5% or greater was cost-effective [ 30].
Indeed, in most of the trials comparing IDeg/IDegAsp with a comparator arm, the incidence of cardiovascular events was estimated according to composite criteria of MACE (major adverse cardiovascular events) and MACE+.
Fewer than 8% of a cohort of metformin users were diagnosed with cancer during a maximum of 10 years of follow-up, compared with 11% of a comparator cohort of nonusers.
A successive clinical study currently being conducted aims to compare the safety and efficacy of Princess VOLUME with a comparator product for the treatment of nasolabial folds.
To control for confounding by indication, analyses were also conducted on a propensity-matched set, wherein each patient from the MMX mesalazine cohort was matched one to one with a comparator patient by decile of propensity scores (i.e., the probability of being prescribed MMX mesalazine versus comparator, regardless of actual drug received).
Of the trials with a comparator group, an AE (postoperative atrial fibrillation) was reported for 1 of 36 (3%) patients receiving fibrinogen concentrate compared with 7 of 37 (19%) of patients in the comparator groups [ 26, 54, 55, 71].
Dr Heslop says it is too soon to draw firm conclusions from the findings - the final results will be published in March 2013, along with results from a comparator group of 60 people who did not have learning disabilities.
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