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It ended the year with assets under management worth £6.4bn, up in a year from £5.4bn which represents an increase of 19%, compared with a comparator market figure of 13%.
Results were analysed with the delta-delta method normalised to two housekeeping genes (Ppia and Rpl13a or UBC and TBP for mouse and human samples, respectively) and compared with a comparator sample (nonclonogenic luminal (NCL) cells).
In clinical trials, outcomes may be measured as: the mean difference in the total score on a given scale between active treatment and comparator groups; the delay to reaching specific milestones; or the percentage of 'responders' to treatment compared with a comparator treatment group or placebo.
Indeed, in most of the trials comparing IDeg/IDegAsp with a comparator arm, the incidence of cardiovascular events was estimated according to composite criteria of MACE (major adverse cardiovascular events) and MACE+.
They compared the incidence of fractures in over 8100 patients treated with pioglitazone compared to over 7400 patients treated with a comparator.
A successive clinical study currently being conducted aims to compare the safety and efficacy of Princess VOLUME with a comparator product for the treatment of nasolabial folds.
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In the majority of trials, investigators are seeking to establish that there are no clinically unacceptable differences in safety compared with either a comparator drug or placebo.
14 Long-term extensions of these studies (total study duration 76 206 weeks) also demonstrated sustained incremental efficacy with saxagliptin compared with placebo or a comparator.
If licensing studies were controlled with placebo or a comparator not relevant to standard care in England, modeling may be used to indirectly compare study arms from separate studies with a common comparator (Section 2.5 GMS TAPS 5).
Evaluated outcomes with reference to a comparator or control, irrespective of research design.
Figure 5 shows the various elements influencing the impact of the new manufactured product with respect to a comparator.
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