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The phrase "with a backbone of" is correct and usable in written English.
It can be used to describe something that is supported or strengthened by a fundamental principle or core element. Example: "The project was designed with a backbone of sustainability, ensuring that all practices were environmentally friendly."
Exact(30)
Ms. Prinz seems a more delicate, less complicated grandmother than Ms. Worth, but with a backbone of steel.
If all four nucleotides formed naturally, then they zipped together easily to form an RNA molecule with a backbone of alternating sugar and phosphate groups.
Organic compounds are characterized as those compounds with a backbone of carbon atoms, and all the remaining compounds are classified as inorganic.
Specificity is dependent to some extent on the degree to which a particular molecular structure can be modified; for example, there are more possible permutations of the structure of a molecule with a backbone of 10 carbon atoms than of a molecule with a backbone of only 2 carbons.
The Rocket, a behemoth Class 1 iceboat with a backbone of 50 feet and 900 square feet of sail, is poised to take the ice, after a lengthy and loving restoration.
Vince Gilligan, the creator of "Breaking Bad," wanted Skyler to be a woman with a backbone of steel who would stand up to whatever came her way, who wouldn't just collapse in the corner or wring her hands in despair.
Similar(29)
Both are graceful examples of Sonoma Coast Pinot Noir, with a soft, silky texture, a backbone of acidity coupled with a tangy minerality and slow-ripened fruit that tastes of plums and dark cherries.
For starters, Quora is built from the ground-up with the Interest Graph being a backbone of the framework.
The backbone atoms of the core region from K1584 to E1600 of PHD3 were fit to the core region of the BPTF PHD with a backbone rmsd of 0.93 Ǻ.
Two more hydrogen bonds are formed by the D ring with a backbone amide of the P-loop and the side chain of Glu239 (Table 1).
Xylans are heterogeneous polysaccharides with a backbone consisting of β-1,4 linked d-xylosyl residues.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com