Theorem 3.2 establishes the result that the point-wise rate of convergence of (|M_{n}/alpha_{n}|^{1/beta_{n}}operatorname{sign}(M_{n})) to the extreme value df (exp -x^{-1})) is of thexp -x^{-1}(O(x^{-1}(log x)^{2} exp -x^{-1}g n)^{-1})).
To evaluate the likelihood of DE we use FDR that has been proposed as a good strategy to handle the increasing family wise error rate of multiple testing [23], [110], [111].
Correcting of a family wise error rate of 0.05 for 17 comparisons gives an adjusted significance level equal to 0.003.
For a family wise error rate of 5% (with a 4 Mb kernel width), we selected 3,663 (12.3%) recurrent deletions and 2,524 (8.5%) recurrent amplification.
It further holds true that the family wise FP rate of peak calling, with or without de-clumping, remain unchanged (Zhang, 2008), and hence our method can control both family wise FP rate and FDR.
In some cases further exploration of significant interactions were completed by post-hoc individual means comparisons using the Bonferroni correction to maintain an overall (family wise) error rate of p < 0.05.
Suppose an m × n mutation matrix A is generated by the D > P model with D = k, the family wise error rate of the test is α = 1 2 n ε and Algorithm 1RMG outputs.
In their paper, the decision to drop a treatment need not be dictated by a predetermined rule based on efficacy data but, if it is, the family wise error rate of the trial can be controlled in the strong sense.
Composite interval mapping [ 71] was conducted with PLABQTL [ 72] with cofactor selection performed following PLABQTL's recommendations and using an " F-to-enter" and an " F-to-delete" value of 7. A LOD threshold of 2.4 was determined by permutation tests that ensures an experiment wise error rate of p < 0.20.
Columns in order are: chromosome, start coordinate of block, end coordinate of block, difference of average probe methylation per set within block, area (block length X difference of average probe methylation per set within block), P value for block difference significance, family-wise error rate of block difference, P value area and family-wise error rate area.
