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The outcome demonstrated 7 interesting clusters (see discussion below) with notable differences between yeast species comparing hypoxic and normoxic conditions, and 2 clusters (6 and 8) with a very similar profile for the pair wise oxygen comparisons and yeast species.
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"A fresh oxygen".
Numbers reflect the regulated genes derived from pair wise comparisons between oxygen set-points, considering a p-value threshold ≤ 0.05 and a log2 fold change cut-off of 0.59.
For pair wise comparisons of the oxygen conditions, the type of gene regulation (up- or downregulated) always refers to the lower oxygen set-point.
Pair wise comparisons of successive oxygen levels and of the anaerobic and fully aerobic conditions are shown in Table 1.
Voxel-wise analysis of dual oxygen and gadolinium challenge has potential to quantify and map tumour hypoxia as prognostic, predictive and pharmacodynamic biomarkers that could facilitate personalised healthcare.
Flow-reactor experiments introducing 0.15 vol% C3H8 while changing the oxygen concentration step-wise (step-response experiments) from rich to lean composition or periodically (pulse-response experiments) switching between rich and lean O2 concentrations, at a constant inlet gas temperature of 250 °C have been performed.
Pair wise fold changes between conditions of different oxygen provision were calculated and the fold changes were used to calculate Z scores for the gene sets.
Plaut and Gordon [15] reported on oxygen consumption rates during group-wise swimming.
These enriched functional groups were analyzed with the fold change values of the pair wise comparisons, i.e. hypoxic vs. normoxic (HvsN), hypoxic vs. oxygen-limited (HvsL), and oxygen-limited vs. normoxic conditions (LvsN).
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