SRP GTPases are regulated not at the point of nucleotide binding or exchange, but rather through a 'step-wise' mechanism.
We have thus proposed a step-wise mechanism of irreversible assembly of single filaments/bundles into thicker bundles, followed by their elongation.
In a step-wise mechanism, the ester bond order would be maintained through formation of a distinct tetrahedral intermediate.
Indeed, if both ER2H2 and ER2 do exist, than ER2H has to be included into consideration based on the step-wise mechanism of binding/dissociation of two hormone molecules to/from ER2H2.
Instead, a pair wise competition mechanism is introduced, where the particle that loses the competition will update its position by learning from the winner.
Such studies revealed a step-wise melting mechanism for these compounds, as indicated by the presence of several pre-melting transitions in their phase sequences [20, 31].
With the help of intermediate objects found in TEM images, it is proposed that the formation of MWCNTs follows a particle-wire-tube step-wise evolution mechanism.
Our results demonstrate that in the absence of Epe1, heterochromatin can spread or collapse without active RNAi, therefore, suggesting that Epe1 may prevent heterochromatin from spreading and collapsing via the step-wise assembly mechanism.
We found that all SNARE complexes assemble by the same step-wise zippering mechanism: slow N-terminal domain (NTD) association, a pause in a force-dependent half-zippered intermediate, and fast C-terminal domain (CTD) zippering.
Mechanism wise, we show that both decitabine and carboplatin reduced binding of MBPs to hypermethylated genes as well as inhibited HP1α, resulting in an increase in H3K4me3 and H3K9 acetylation, the active histone marks associated with gene reactivation.
A PCP-wise budget distribution mechanism is proposed to balance budget among partial critical paths according to their sequential or parallel structure nature.
