The thymus is the site of step-wise maturation of naïve T cells from immature thymocytes which occurs along with positive and negative selection processes while thymocytes migrate from the cortex to the medulla.
Also, we present the crystallographic analyses of both the initial and the improved Anticalin, providing insight into the molecular mechanism of chelated metal binding and the role of amino acid substitutions during the step-wise affinity maturation.
Using quantitative VFM maps from 198 (81 female) infants, we construct a voxel-wise probabilistic model of VFM maturation.
Here, we propose a concept for improving the ligand-binding properties of this anticalin in an in vitro affinity maturation process by step-wise randomization of restricted areas of the loop region.
Time-wise Expression of Penicillium camemberti Genes, Related to Figure 2 Time-wise expression of Penicillium camemberti genes during cheese rind maturation; these data were generated in a previous study [36].
These proteins are degraded step-wise from the matrix by MMP20 and KLK4 at ameloblast secretory stage and maturation stage, respectively [ 2].
Voxel-wise estimates of age represent an unique method to examine the time course of brain maturation.
They are subsequently degraded step-wise from the matrix by MMP20 and kallikrein 4 (KLK4) during the ameloblast secretory stage and maturation stage, respectively [ 2].
These results provide a strategy, consisting of step-wise induction of organs, including induction of the organ-forming field, the organ rudiment and organ maturation, for initiating organogenesis using specific organ-inductive signalling molecules for various types of organ regeneration.
Based on their finding that evolutionary trends to earlier maturity resulting from fisheries that target late-maturing individuals can be associated with step-wise, 1-year shifts in age at first reproduction, De Roos et al. (2006) hypothesized that early maturation at small sizes and late maturation at large sizes may represent alternative evolutionarily and ecologically stable states.
An experiment-wise type I error rate α = 1 × 10-3 was used to identify transcripts differentially expressed across maturation stages.
