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Each map was statistically corrected for multiple comparisons using a voxel-wise (intensity) threshold of p<.001 and a cluster-wise (extent) threshold of 8 voxels.
But the more you hear of this early version, the more you suspect that they may have been very good students indeed and, to a considerable extent, wise counselors.
-ROBERT LOUIS STEVENSON The fool who knows his foolish-ness is wise to that extent.
Next he cautions that no one can know all things; so a person is wise to the extent that he knows (IV.vi.7).
'I'll never get over the fact that my son was riddled with cancer and I was none the wiser, to the extent that it was only by chance that he was [diagnosed]' (Mother of child, 14 years, rhabdomyosarcoma).
For this reason, our first imaging results are based on whole-brain contrasts, at a relatively liberal statistical threshold (initial cluster forming threshold Z>2, family wise error corrected cluster extent threshold p<0.05).
In 31/33 analyses, the effect sizes for PIQ were significant (p < 0.05 in extent) after family wise error correction for multiple comparisons across the whole brain.
The extent of pair-wise linkage disequilibrium (r-value) between polymorphisms was determined by the Haploview version 4.2.
To assess the extent of pair-wise linkage disequilibrium between SNPs, standard definition of D′ and r were calculated using Haploview software.
> -wrap-foot> a. Empty cells indicate no grey matter correlates were identified at the voxel-wise (P<0.001 uncorrected) and cluster extent (50 voxel) thresholds used.
Second-level group-level random-effects analysis was thresholded at p < 0.05 corrected for multiple comparisons with family-wise error correction with an extent threshold of 8 voxels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com