That, the opera-wise brain trust advises, isn't quite on the money.
What we perceive as a brain in flight or decline, disengaging from the world or tumbling into a netherworld of oldness, might actually be a more selective, creative and wiser brain.
Whole vertex-wise brain comparisons revealed cortical thinning in the precentral gyrus in patients with ALS compared to healthy controls as illustrated in Figure 2 (left and right precentral gyrus: p<0.0001 and p<0.001, respectively).
Voxel-wise brain activation was compared between the NCD and noNCD-groups using the following two-level analytic approach.
Pair-wise brain sections of mice from the HC and N15 (or N60) groups were mounted on the glass slides and processed for immunohistochemistry in the same solutions.
Speech and non-speech were compared using voxel-wise whole brain analyses, and ROI analyses focused on frontal and temporoparietal structures previously reported to support speech production.
Hypothesis-driven methods, such as the general linear model (GLM), which regress exterior stimulus from voxel-wise functional brain activity, are limited due to overlooking the complexity of brain activities and the diversity of concurrent brain networks.
Unless specified otherwise in the result section, we employed FWE cluster-level correction for multiple comparisons of the voxel-wise whole brain analysis throughout this study, and used cluster p<.05 (FWE corrected) in conjunction with voxel height threshold p<.01 to identify significant changes in BOLD signal between task conditions.
To better localize significant decreases in BOLD signal in this large cluster, we reanalyzed the contrast of high load [with distractors vs. without distractor] using cluster-based FWE corrected p<.05 for multiple comparisons of voxel-wise whole brain analysis in conjunction with voxel high threshold p<.001.
In the current paper, we describe the first voxel-level pair-wise whole brain comparison of resting state functional connectivity differences between subjects with autism and controls.
Hence, given the complexity and multiple causes of autism together with variability between individuals, a novel, unbiased approach is urgently called for which identifies pathway changes in a whole-brain voxel-based manner and Gotts et al. (2012) have described a voxel-wise whole brain comparison of functional connectivity differences between autism and controls.
