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Another winner, Design Seoul, addresses the problems of an entire city.
An example of a response adaptive design that has received much attention in recent years is the randomized play the winner design (RPWD).
In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials.
However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis.
In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control.
In order to test the best performing radiation dose with a convenient chemotherapy schedule of an oral formulation of radio-sensitizing vinorelbine in inoperable locally advanced non-small cell lung cancer (NSCLC), we performed a randomized phase II trial based on a "pick the winner" design.
Similar(54)
Shigeru Ban, last year's Japanese winner, designs paper-tube structures that can be quickly erected to house disaster victims.
The company has fabricated furniture, fittings and hardware for the architect's own Upper East Side duplex and, more recently, bases of the 27 stainless-steel tables with translucent resin tops that Meier, a Pritzker Prize winner, designed for 66, Jean-Georges Vongerichten's new restaurant.
Judges praised the "calm beauty" of the winner, designed by Stanton Williams.
This year's winner, designed by David Benjamin of New York architects The Living, is, simply put, a mushroom tower.
This paper develops a unified method to compute the exact statistical power for a general class of response adaptive designs including the randomized play-the-winner design, the drop-the-loser design, and the doubly biased coin design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com