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Instead, remaining winner cells increase in size by accelerating their endocycles in a process named compensatory cellular hypertrophy [ 12 ].
These findings demonstrate that, as in Drosophila, the relative expansion of winner cells is dependent on the purging of cells with lower relative levels of Myc.
Competitive interactions between cells in a compartment or between stem cells in a niche, already select, better endowed, more competitive winner cells and their descendants [ 105, 106].
ONCs can be induced by cell competition, a process in which normally viable "loser" cells are eliminated by neighboring "winner" cells.
'Winner' cells actively eliminate 'loser' cells by inducing apoptosis and thereby take over the tissue (Moreno et al., 2002; Moreno and Basler, 2004; de la Cova et al., 2004).
Cell competition is a cellular phenomenon that occurs when two populations of cells of different "fitness" encounter, and the cells with "fitness advantages", termed "winner cells", rapidly expand at the expense of the less fit cells, termed "loser cells" [ 60].
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Reciprocally, a winner cell that corresponds to a correct location-scene pair may fail to receive reward if the decision stage chooses a wrong location by chance.
However, because the cells exhibit a medium activity level in their dynamic range relative to the parameters θ and τ, a winner cell's probability of selecting its associated location is around 0.5, leading to occasional incorrect choices when the winner is a correct cell, and to correct choices when the winner is an incorrect cell.
At the end of each trial, the input weights of the winner cell C Xw are updated according to the TD algorithm (Eqs. (3) and (4)) using a reward of 1 (0) if the model's choice is correct (incorrect).
According to this rule, if the decision mechanism fails to choose the location associated with the winner cell with probability, then a location is selected with equal probability among the four possibilities.
Therefore, in this scheme, a winner cell that corresponds to an incorrect location-scene pair may nonetheless get reward if the decision stage chooses the correct location by chance.
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