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If on the second test any window tests positive then that too is deemed abnormal and the subject is referred to the SSP clinic.
For example, for a MAF threshold of 0.01, the smallest sections contained m = 72 or 73 window tests each (74,156/1,024).
For each section, we calculated the minimum P-value for the window tests, for the single-SNP tests, and for both windows and single SNPs combined, for each of the 1,000 simulations.
The estimates we have obtained for genome-wide significance thresholds may vary if we had used another chromosome for our simulations, or if we had incorporated multiple window tests into our analytic strategy.
Because the whole genome is approximately 15.6 times longer than chromosome 3, we therefore created a new point on the x-axis at x* = −log10 0.05/(15.6 m max3)), where m max3 is the total number of tests on chromosome 3 (e.g., m max3 = 74,156 for window tests and MAF threshold = 0.01).
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Then, before I lost too much sunlight, I grabbed the coffee filters and the squeegee for a side-by-side window test.
Cyclic voltammetry, galvanostatic charge/discharge and wide potential window test are carried out to evaluate the electrochemical performances of the carbon electrodes.
For those that don't remember, Notch bought Aphex Twin's unreleased Caustic Window test pressing for $46 million on eBay, so a love of electronic music is clearly a recurring theme in the Minecraft world.
We used sliding window testing with corrections for multiple testing within each studied region.
Moreover, this timing fits with the time window tested by Pitcher et al. (2008).
For each simulated phenotype, we calculated and stored all single-SNP test P-values and all window test P-values for MAF thresholds of 0.005, 0.01, and 0.05.
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