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The study of these relationships, by means of up front window studies in children who present with high-risk disease, may be as important as the introduction of new agents.
Indicative of a therapeutic window, studies in mice using a BiTE binding to murine EpCAM and murine CD3 demonstrated anti-tumor activity in the absence of damage to EpCAM-expressing normal epithelia [37], [41], [42].
Although we cannot rule out any contribution that the enhanced weight loss had on the cognitive improvements we observed, our time window studies suggest that this was unlikely to be a determining factor.
There have been two other reported preoperative window studies of metformin in newly diagnosed endometrial cancer patients 40, 41.
Similar to the other preoperative window studies in breast and endometrial cancer 18, 40, we found that metformin significantly decreased phosphorylation of downstream targets of the mTOR pathway, including p-Akt, p-S6, and p-4E-BP-1.
Preoperative window studies of metformin in patients planning to undergo surgical resection of breast cancer have shown promising results in metformin's ability to reduce proliferation indices (i.e., Ki-67) and increase apoptosis 18– 20.
Similar(54)
They look out the window, study maps, peer at signs.
He propped his muddy bare feet on the bench where Bale was sitting, put on some mirrored glasses, and stared out the window, studying the landscape.
Just two years later, Lichtenstein's cartoonlike "Girl in Window (Study for World's Fair Mural)" and Warhol's silver-colored "Elvis 2 Times," occupy separate conceptual galaxies.
I spent the time pressing my nose against the window, studying passers-by for yoga mats and bags from the farmers' market — signs that nobody told them how to spend their hour.
The delicate pathos and subtle comedy of their romance is a joy, and there is wonderful audacity in the way Ray shows Charulata's life at the beginning – simply looking out of the window, studying the passersby with the engaged curiosity of a true artist.
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