Unfortunately, using multiple antibodies against AKAP13, the IHC signal was high in most cells with a minimal dynamic window, precluding a reliable categorization of the samples based on IHC.
While a model simultaneously adjusting for all exposure periods at once is more desirable than separate models, the high correlation of usage across the exposure windows precludes meaningful inference from such a model.
The exclusion criteria included the presence of prosthetic heart valves or inadequate echocardiographic windows precluding comprehensive assessment of valve leaflet morphology, mobility and thickening.
Four patients were lost to follow up and seven patients were excluded owing to inadequate echocardiographic windows precluding clear visualisation of all valves, resulting in a total of 137 patients studied (see Figure 1).
While this format provides a solution environment, the diffusion limited temporal window (∼ms) precludes the investigation of slow (>10 ms) dynamics.
This exceptional behaviour is caused by a limited operative absorption time (or absorption window) in class III drugs that precludes complete absorption and produces a non-linear absorption.
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This approach has increased resolution but precludes statistical analysis because overlapping windows are not independent.
These windows were chosen to preclude exposures that may have occurred after diagnosis and to allow us to separately examine preconceptional exposures, which we hypothesized could increase maternal systemic oxidative stress or inflammation, and postconceptional exposures, which could adversely affect placentation (Brook 2008; Roberts et al. 2003).
Twenty-nine of the 42 respondents felt it acceptable to commence a drug trial before consent was obtained if the time window for initiation of treatment was narrow and therefore precluded obtaining consent.
