The murine dorsal skinfold window chamber model was used to evaluate the structural remodeling response of the microvasculature.
The present review describes window chamber methods and hardware, the measurement of oxygen, and the introduction into the chamber of tumors, growth factors, and organs to induce angiogenesis.
We developed a rodent dorsal skinfold window chamber that facilitated both MRI and non-invasive optical imaging of nanoparticle accumulation in the same tumors.
The nanoparticle design and MR imaging developed with the window chamber were then extended to orthotopic pancreatic tumors expressing DsRed-2.
Tissue oxygen levels can be measured during the course of angiogenesis using a window chamber that is also fitted with a miniature multiple electrode sensor.
In the hamster window chamber model, packed fresh RBC improved but not completely normalized functional capillary density and flow [17, 18].
Vasculature was imaged through the window chamber using fluorescent microscopy.
and xylazine (10 mg/kg i.p ., and window chamber surgeries were performed under sterile conditions [2].
The concentrated form of pharmaceutical grade rEPO (Procrit, 40,000 units/ml) permitted the maximum administration of 280 units into each window chamber.
Using the dorsal skin-fold window chamber angiogenesis model, we focused on erythropoietin blockade during the initial stages of tumorigenesis by employing local antagonists targeting erythropoietin function.
The transparent window chamber allowed non-invasive diffusion measurements.
