The blood supply must be adequate to supply the separated flap and wound edge with nourishment.
The data include wound measurement variables, for example, wound edge distance, temperature, include exudate amount, etc.
Upon addition of the compound, wound edge translocation was greatly inhibited, and actin aggregates began to accumulate in the cells.
For example, Figure 3A shows calcium concentration at unwounded cornea (time 0) and at wound edge (wound edge has a relatively higher concentration).
By day 15 (Fig. 2E to H), wounds in all treatment groups displayed wound edge rounding, indicative of contracture.
In Baz Xi106 mutants, in which junction shrinking was also reduced, wound edge movement was similarly inhibited (supplementary material Fig. S3D).
It also undergoes EMT at the monolayer wound edge in "scratch" assays which is synergistic with EGF-induced EMT (M. Leigh Ackland, unpublished observation).
The rationale lies in removing necrotic, devitalized wound bed and wound edge tissue that inhibits healing, so that secondary wound healing can be achieved [ 22].
We observe occasional junctional rises in myosin intensity as myosin pulses developed in wound edge cells, but these rises generally resolved (supplementary material Fig. S2Dii).
Wound complications can be divided into minor complications (superficial infection, dehiscence, wound edge necrosis) and major complications (deep infection, osteomyelitis, plate fistula) [ 12].
