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2) The manuscript would also benefit from discussion of the proposed mechanism by which the WIN compounds block infection.
WIN compounds and related molecules prevent receptor attachment/uncoating of a number of enteroviruses (Pevear et al., 1999).
Two of the most extensively characterized series of capsid-binding agents are the so-called WIN compounds, developed by Sterling Winthrop (New York, NY, USA), and a series of pyridazine analogs developed by the Janssen Research Foundation (Beerse, Belgium).
The relatively high affinity between the pocket and WIN compounds prevents the conformational changes necessary for uncoating, increasing capsid stability (Rotbart et al., 1998) and can be effective at preventing infection in culture (Pevear et al., 1999, Shia et al., 2002, Benschop et al., 2015), and murine models (Groarke and Pevear, 1999, Liu et al., 2012).
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The winning compound, now called neotame, is a version of aspartame created by Nofre and Tinti.
Brown won compound gold in both Beijing and London but she has also competed in able-bodied competition, winning compound team gold for England at the 2010 Commonwealth Games in Delhi.
Brown won compound gold in both Beijing and London but she has also competed for GB in able-bodied competition and won compound team gold for England at the 2010 Commonwealth Games in Delhi.
Stubbs won the compound men's team event along with Richard Hennahane and Eric Thomas.
June 16, 1897 Berlin, Germany August 26 , 1987Heidelberg, Germany Georg Wittig, (born June 16, 1897, Berlin, Ger. died Aug. 26, 1987, Heidelberg, W.Ger). German chemist whose studies of organic phosphorus compounds won him a share (with Herbert C. Brown) of the Nobel Prize for Chemistry in 1979.
Georg Wittig, (born June 16, 1897, Berlin, Ger. died Aug. 26, 1987, Heidelberg, W.Ger). German chemist whose studies of organic phosphorus compounds won him a share (with Herbert C. Brown) of the Nobel Prize for Chemistry in 1979.
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