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We suspect the very high PCNA signals at origin sites in the 15-min time point in the elg1Δ mutant, compared to ELG1+, reflect delayed unloading of PCNA (as opposed to PCNA over-loading at replication initiation), since PCNA unloading will begin as soon as lagging-strand replication is established and will therefore already have begun to occur at the 15-min time point in ELG1+ cells.
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In many instances, it will therefore be already too late to adapt to such events once their impacts become observable within the frame of the adaptive cycle.
European political parties will therefore, or have already, put forward their candidates for this leading position in the EU before the European elections, thus allowing citizens to have a say over next Commission President.
The selection committee will therefore probably choose someone already senior at another university or from within Harvard, predicts William Funk of executive recruitment firm Korn/Ferry International, who helps universities find new presidents.
The Social Democratic Group will therefore do what it already decided to do weeks ago in the light of present knowledge.
We will, therefore, exclude people who are already registered organ donors from the main analyses.
"This accounting adjustment relates to money already spent and will therefore not have an effect on the company's operating earnings," Mr. Feting said.
Each generation will therefore tend to reproduce the most salient thus already "proven"—cultural and political models of the previous generation.
They will therefore need more and more water, which is already scarce, while pollution and environmental change are threatening even the existing water resources.
Lavezzi received a yellow card, knowing that he was already on a caution, and will therefore also miss the return match in Paris next month.
Broadcom has no knowledge of the mainframe software industry and will therefore be unable to do anything to improve the already weak performance of CA's management team.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com